Tetrabenazine (Racemate)

Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2) . (1) The reference for administration is 0.25-0.75 mg/kg IP (2) Injections of tetrabenazine into accumbens core also reduced FR5 lever pressing and increased chow intake. (3) Tetrabenazine (Racemate) reduced extracellular DA and altered DARPP-32 signaling in both substance-P- and enkephalin-containing accumbens neurons. (4) Tetrabenazine (Racemate) inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.

Product Specifications

CAS Number

[718635-93-9]

Product Name Alternative

Ro 1-9569 (Racemate)

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Monoamine Transporter

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3C2C1

Molecular Formula

C19H27NO3

Molecular Weight

317.42

Precautions

H315, H319, H320

References & Citations

[1]Nunes EJ et al. Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression. J Neurosci. 2013 Dec 4;33 (49) :19120-30.|[2]Podurgiel SJ et al. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor. Neuroscience. 2013 Oct 10;250:507-19.|[3]Reches A et al. Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. J Pharmacol Exp Ther. 1983 Jun;225 (3) :515-21.