Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Cyclosporin A-d12

Cyclosporin A-d12 (Cyclosporine A-d12) is deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8].

Product Specifications

Product Name Alternative

Cyclosporine A-d12; Ciclosporin A-d12; CsA-d12

UNSPSC

12352211

Target

Antibiotic; Complement System; Cyclophilin; Isotope-Labeled Compounds; Molecular Glues

Related Pathways

Anti-infection; Immunology/Inflammation; Others; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Smiles

C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@](C(C)C)(N(C([C@@H](N(C([C@](CC(C)C)(N(C([C@H](NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@@](NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](CC)NC1=O)=O)=O)=O)(C(C)C)[H])=O)=O)C)=O)C)=O)C)[H])=O)C([2H])([2H])[2H])C([2H])(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[2H])=O)C)[H])=O)C)O

Molecular Formula

C62H99D12N11O12

Molecular Weight

1214.69

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Dalmarco EM, et al. Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan. Cell Adh Migr. 2008 Oct-Dec;2 (4) :231-5.|[3]Fruman DA, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 1;89 (9) :3686-90.|[4]Flanagan WM, et al. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991 Aug 29;352 (6338) :803-7.|[5]Nicolli A, et al. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. J Biol Chem. 1996 Jan 26;271 (4) :2185-92.|[6]Borel JF, et al. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology. 1977 Jun;32 (6) :1017-25.|[7]Williams, R, et al. Randomised trial comparing FK506 and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. Lancet, 1994, 344 (8920), 423-428.|[8]Liu J, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66 (4) :807-15.|[9]Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226 (4674) :544-7.|[10]Medeiros M, et al. Increased cyclosporine bioavailability induced by experimental nephrotic syndrome in rats. Can J Physiol Pharmacol. 2007 May;85 (5) :502-6.|[11]Nguyen LT, et al. Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse. Sci Rep. 2021 Jun 14;11 (1) :12437.|[12]Ling H, et al. Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation. J Am Soc Nephrol. 2003 Feb;14 (2) :377-88.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit
MBS9938722-01 48 Well

Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit

Ask
View Details
Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit
MBS9938722-02 96 Well

Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit

Ask
View Details
Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit
MBS9938722-03 5x 96 Well

Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit

Ask
View Details
Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit
MBS9938722-04 10x 96 Well

Canine RepliCation Protein A 14 kDa Subunit (RPA3) ELISA Kit

Ask
View Details
Rat p-JNK (Phosphorylated c-Jun N-terminal kinases) ELISA Kit
EK240473 96 Well

Rat p-JNK (Phosphorylated c-Jun N-terminal kinases) ELISA Kit

Ask
View Details
TYRO3 3'UTR Lenti-reporter-Luc Vector
48893081 1.0 µg

TYRO3 3'UTR Lenti-reporter-Luc Vector

Ask
View Details