Tetrahydrozoline-d4 (hydrochloride)

Tetrahydrozoline-d4 (hydrochloride) is the deuterium labeled Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

Product Specifications

CAS Number

[1246814-66-3]

Product Name Alternative

Tetryzoline-d4 (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Cardiovascular Disease; Endocrinology

Purity

99.80

Solubility

10 mM in DMSO

Smiles

[2H]C1([2H])C([2H])([2H])NC(C2C3=CC=CC=C3CCC2)=N1.Cl

Molecular Formula

C13H13D4ClN2

Molecular Weight

240.77

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190 (40) :E1208.|[3]Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS) . Methods Mol Biol. 2010;603:501-8.|[4]Danuta Nowakowska, et al. In vitro effects of vasoconstrictive retraction agents on primary human gingival fibroblasts. Exp Ther Med. 2020 Mar; 19 (3) : 2037-2044.