Tetrahydrozoline (hydrochloride)

Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

Product Specifications

CAS Number

[522-48-5]

Product Name Alternative

Tetryzoline (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Purity

99.88

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

C1(C2CCCC3=C2C=CC=C3)=NCCN1.Cl

Molecular Formula

C13H17ClN2

Molecular Weight

236.74

Precautions

H302, H315, H319, H335

References & Citations

[1]E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190 (40) :E1208.|[2]Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS) . Methods Mol Biol. 2010;603:501-8.|[3]Danuta Nowakowska, et al. In vitro effects of vasoconstrictive retraction agents on primary human gingival fibroblasts. Exp Ther Med. 2020 Mar; 19 (3) : 2037-2044.