Biotin-13C5
Biotin-13C5 (Vitamin B7-13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3].
Product Specifications
Product Name Alternative
Vitamin B7-13C5; Vitamin H-13C5; D-Biotin-13C5
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=[13C](O)[13C][13C][13C][13C][C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Molecular Formula
C5 13C5H8N2O3S
Molecular Weight
241.21
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Zempleni, et al. Biotin biochemistry and human requirements. J Nutr Biochem, 1999. 10 (3) : p. 128-38.|[3]Mock, D.M.. Biotin status: which are valid indicators and how do we know? J Nutr, 1999. 129 (2S Suppl) : p. 498S-503S.|[4]Zempleni J, et al. Biotin. Biofactors. 2009 Jan-Feb;35 (1) :36-46.|[5]Vadlapudi AD, et al. Biotin uptake by T47D breast cancer cells: functional and molecular evidence of sodium-dependent multivitamin transporter (SMVT) . Int J Pharm. 2013 Jan 30;441 (1-2) :535-43. |[6]Sghaier R, et al. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radic Res. 2019 May;53 (5) :535-561. |[7]Aldahmash BA, et al. Biotin amelioration of nephrotoxicity in streptozotocin-induced diabetic mice. Saudi J Biol Sci. 2015 Sep;22 (5) :564-9. |[8]He P, et al. Dietary biotin deficiency decreased growth performance and impaired the immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella) . Fish Shellfish Immunol. 2020 Feb;97:216-234.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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