Trimethoprim (lactate) (Standard)

Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo[1][2][3].

Product Specifications

CAS Number

[23256-42-0]

UNSPSC

12352005

Target

Antibiotic; Antifolate; Bacterial; Reference Standards

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Others

Field of Research

Infection; Cancer

Smiles

CC(O)C(O)=O.NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1

Molecular Formula

C17H24N4O6

Molecular Weight

380.40

References & Citations

[1]Ewa Laskowska, et al. Trimethoprim Induces Heat Shock Proteins and Protein Aggregation in E. Coli Cells. Curr Microbiol. 2003 Oct;47 (4) :286-9.|[2]R N Brogden, et al. Trimethoprim: A Review of Its Antibacterial Activity, Pharmacokinetics and Therapeutic Use in Urinary Tract Infections. Drugs. 1982 Jun;23 (6) :405-30.|[3]Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.|[4]El Habbal MH. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virol J. 2021 Jun 3;18 (1) :113.