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Quinapril-d4

Quinapril-d4 (CI-906-d4) is deuterium labeled Quinapril. Quinapril is a potent, orally active, non-peptide and nonsulfhydryl inhibitor of angiotensin-converting enzyme (ACE) . Quinapril specifically interrupts the conversion of angiotensin I to angiotensin II in both plasma and tissue. Quinapril is enzymatically hydrolyzed to a pharmacologically active diacid form quinaprilat. Quinapril is efficacious in hypertensive models[1].

Product Specifications

Product Name Alternative

CI-906-d4

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@@H](CC3=C([2H])C([2H])=C([2H])C([2H])=C3C2)C(O)=O)=O)=O

Molecular Formula

C25H26D4N2O5

Molecular Weight

442.54

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kaplan HR, et, al. Quinapril--a preclinical review of the pharmacology, pharmacokinetics, and toxicology. Angiology. 1989 Apr;40 (4 Pt 2) :335-50.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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