Domperidone-13C6
Domperidone-13C6 (R33812-13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
Product Specifications
Product Name Alternative
R33812-13C6
UNSPSC
12352005
Target
Dopamine Receptor; Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN(C(NC)=O)C)CC3.[13CH]4=[13CH][13CH]=[13CH][13CH]=[13CH]4
Molecular Formula
C18 13C6H32ClN5O2
Molecular Weight
463.95
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102 (9) :2036-2045.|[3]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135 (5) :457-461.|[4]Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124 (1) :52-60.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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