Domperidone-13C6

Domperidone-13C6 (R33812-13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].

Product Specifications

Product Name Alternative

R33812-13C6

UNSPSC

12352005

Target

Dopamine Receptor; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN(C(NC)=O)C)CC3.[13CH]4=[13CH][13CH]=[13CH][13CH]=[13CH]4

Molecular Formula

C18 13C6H32ClN5O2

Molecular Weight

463.95

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102 (9) :2036-2045.|[3]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135 (5) :457-461.|[4]Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124 (1) :52-60.