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(1S,2R,7S) -Sitafloxacin

(1S,2R,7S) -Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin (HY-B0395) . (1S,2R,7S) -Sitafloxacin is a topoisomerase inhibitor. (1S,2R,7S) -Sitafloxacin is an antibiotic. (1S,2R,7S) -Sitafloxacin has inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S) -Sitafloxacin has antibacterial activity and can be used in the study of various bacterial infections[1].

Product Specifications

CAS Number

[127254-11-9]

Product Name Alternative

(1S,2R,7S) -DU-6859a; DU-6856

UNSPSC

12352005

Target

Antibiotic; Bacterial; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O=C(C1=CN([C@@H]2[C@H](F)C2)C3=C(C=C(F)C(N(C[C@H]4N)CC54CC5)=C3Cl)C1=O)O

Molecular Formula

C19H18ClF2N3O3

Molecular Weight

409.81

References & Citations

[1]Akasaka T, et al. Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases. Antimicrob Agents Chemother. 1998 May;42 (5) :1284-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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