Enalapril-d3
Enalapril-d3 (MK-421-d3) is deuterium labeled Enalapril. Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].
Product Specifications
CAS Number
[1356847-94-3]
Product Name Alternative
MK-421-d3
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease; Cancer
Smiles
CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C([2H])([2H])[2H])C(N2[C@@H](CCC2)C(O)=O)=O)=O
Molecular Formula
C20H25D3N2O5
Molecular Weight
379.47
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22 (6) :698-705.|[3]Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease. J Res Med Sci. 2013 Mar;18 (Suppl 1) :S1-5.|[4]Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14 (3) :1150-7.|[5]A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373 (1) :21-33.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0331S1/
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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