Amiloride (Standard)
Amiloride (Standard) is the analytical standard of Amiloride. This product is intended for research and analytical applications. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]) . Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Product Specifications
CAS Number
2609-46-3
UNSPSC
12352100
Target
Apoptosis; Reference Standards; Sodium Channel; TRP Channel
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N
Molecular Formula
C6H8ClN7O
Molecular Weight
229.63
References & Citations
[1]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303 (12) : p. L1013-26.|[2]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20 (1) :109-17.|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29 (7) :1176-91.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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