Prednisone-13C2, d2

Prednisone-13C2, d2 (Dehydrocortisone-13C2, d2) is 13C labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus[1][2].

Product Specifications

Product Name Alternative

Dehydrocortisone-13C2, d2

UNSPSC

12352211

Target

Apoptosis; Glucocorticoid Receptor; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease

Smiles

C[C@@]12[C@](CC([2H])([2H])[C@]2(O)[13C]([13CH2]O)=O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4(C(CC3)=CC(C=C4)=O)C

Molecular Formula

C19 13C2H24D2O5

Molecular Weight

362.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1 (4) :488-96.|[3][2]N Tomioka, et al. Effects of prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol. 1986 Apr;7 (4) :868-72.|[4]Qianqian Li, et al. Metabolic Profiling Reveals an Abnormal Pattern of Serum Fatty Acids in MRL/lpr Mice Under Treatment With Prednisone. Front Pharmacol. 2020 Feb 25;11:115.