Riluzole-13C6
Riluzole-13C6 (PK 26124-13C6) is 13C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
Product Specifications
Product Name Alternative
PK 26124-13C6
UNSPSC
12352005
Target
GABA Receptor; Isotope-Labeled Compounds; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Smiles
NC1=N[13C]2=[13C][13C]=[13C](OC(F)(F)F)[13C]=[13C]2S1
Molecular Formula
C2 13C6H2F3N2OS
Molecular Weight
237.13
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA (A) receptor function. Neuropharmacology. 2002 Feb;42 (2) :199-209.|[3]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 28;11:51.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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