L-Ascorbic acid (magnesium)

L-Ascorbic acid (L-Ascorbate) magnesium, an electron donor, is an endogenous antioxidant. L-Ascorbic acid selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition promoter and elastin production inhibitor. L-Ascorbic acid exhibits anticancer effects by generating reactive oxygen species (ROS) and selectively damaging cancer cells[1][2][3][4].

Product Specifications

CAS Number

[15431-40-0]

Product Name Alternative

L-Ascorbate (magnesium) ; Vitamin C (magnesium)

UNSPSC

12352200

Hazard Statement

H315-H319-H320

Target

Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

95.0

Smiles

OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O.[0.5Mg2+]

Molecular Formula

C6H8O6.1/2Mg

Molecular Weight

187.27

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35. |[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27 (46) :12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75 (3) :173-82. |[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8 (1) :11372.