Ivabradine (sulfate)
Ivabradine sulfate is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If) . Ivabradine sulfate reduces dose-dependently heart rate without modification of blood pressure. Ivabradine sulfate shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].
Product Specifications
CAS Number
1202000-62-1
UNSPSC
12352005
Target
HCN Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease; Neurological Disease
Smiles
O=S(O)(O)=O.O=C(CC1=CC(OC)=C(OC)C=C1CC2)N2CCCN(C)C[C@@H]3C4=CC(OC)=C(OC)C=C4C3
Molecular Formula
C27H38N2O9S
Molecular Weight
566.66
References & Citations
[1]Tardif JC, et al. Efficacy of ivabradine, a new selective I (f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26 (23) :2529-36.|[2]Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105.|[3]Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512.|[4]Du XJ, et al. I (f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142 (1) :107-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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