Ivabradine (sulfate)

Ivabradine sulfate is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If) . Ivabradine sulfate reduces dose-dependently heart rate without modification of blood pressure. Ivabradine sulfate shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].

Product Specifications

CAS Number

[1202000-62-1]

UNSPSC

12352005

Target

HCN Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease; Neurological Disease

Smiles

O=S(O)(O)=O.O=C(CC1=CC(OC)=C(OC)C=C1CC2)N2CCCN(C)C[C@@H]3C4=CC(OC)=C(OC)C=C4C3

Molecular Formula

C27H38N2O9S

Molecular Weight

566.66

References & Citations

[1]Tardif JC, et al. Efficacy of ivabradine, a new selective I (f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26 (23) :2529-36.|[2]Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105.|[3]Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512.|[4]Du XJ, et al. I (f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142 (1) :107-12.