Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Zonisamide-13C6

Zonisamide-13C6 (AD 810-13C6) is 13C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy[1][2][3][4].

Product Specifications

Product Name Alternative

AD 810-13C6; CI 912-13C6

UNSPSC

12352005

Target

Apoptosis; Carbonic Anhydrase; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=S(N)(CC1=NO[13C]2=[13C]1[13C]=[13C][13C]=[13C]2)=O

Molecular Formula

C2 13C6H4N2O3S

Molecular Weight

214.15

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kawajiri S, et al. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett. 2010 Sep 6;481 (2) :88-91. |[3]Ueda Y, et al. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res. 2003 Aug 19;116 (1-2) :1-6. |[4]Wu Q, et al. Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress. Acta Pharmacol Sin. 2021 Oct;42 (10) :1587-1597.|[5]De Simone G, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15 (9) :2315-20.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

3-Cyano-7-ethoxycoumarin
TRC-C987430-100MG 100 mg

3-Cyano-7-ethoxycoumarin

Sign In for Pricing
View Details
4930483J18Rik Mouse siRNA Oligo Duplex (Locus ID 67638)
SR401663 1 Kit

4930483J18Rik Mouse siRNA Oligo Duplex (Locus ID 67638)

Sign In for Pricing
View Details
AES Buffer 0.3M, pH 9.0
40120017-2 250 mL

AES Buffer 0.3M, pH 9.0

Sign In for Pricing
View Details
SMOX Rabbit Polyclonal Antibody
orb1474829 100 µg

SMOX Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
BTBD16 Adenovirus (Human)
13518051 1.0 mL

BTBD16 Adenovirus (Human)

Sign In for Pricing
View Details
CICP11 AAV Vector (Human) (CMV)
16172101 1 µg

CICP11 AAV Vector (Human) (CMV)

Sign In for Pricing
View Details