Oxcarbazepine-d10
Oxcarbazepine-d10 (GP 47680-d10) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
Product Specifications
CAS Number
2749432-28-6
Product Name Alternative
GP 47680-d10
UNSPSC
12352005
Target
Apoptosis; Isotope-Labeled Compounds; Sodium Channel
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
O=C(N)N1C2=C(C([2H])=C(C([2H])=C2C([2H])(C(C3=C(C([2H])=C(C([2H])=C31)[2H])[2H])=O)[2H])[2H])[2H]
Molecular Formula
C15H2D10N2O2
Molecular Weight
262.33
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19 (1) :1-9.|[3]Ching-Yi Lee, et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127 (3) :445-53.|[4]M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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