(S) -Doxazosin

(S) -Doxazosin is a long-acting selective α1-adrenoceptor antagonist. (S) -Doxazosin exhibits antihypertensive activity through lowering total perioheral resistance by selective postsynaptic α1-blockade. (S) -Doxazosin reduces blood pressure in dog model with experimentally induced renal hypertension. (S) -Doxazosin can alleviate bladder outflow obstruction. (S) -Doxazosin can also be studied in mental health disorder-related research[1][2][3].

Product Specifications

CAS Number

[104874-86-4]

Product Name Alternative

(S) -UK 33274

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Smiles

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@H]4OC5=CC=CC=C5OC4

Molecular Formula

C23H25N5O5

Molecular Weight

451.48

References & Citations

[1]Fulton, B., et al., (1995) . Doxazosin. An update of its clinical pharmacology and therapeutic applications in hypertension and benign prostatic hyperplasia. Drugs, 49 (2), 295-320. |[2]Young, R. A., & Brogden, R. N. (1988) . Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. Drugs, 35 (5), 525-541.|[3]Christie S. Richardson, et al., (2025) . Doxazosin for the treatment of mental health disorders: A scoping review. PLOS Mental Health.