Acarbose-d4
Acarbose-d4 (BAY g 5421-d4) is deuterium labeled Acarbose. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM) . Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3].
Product Specifications
CAS Number
[1260619-60-0]
Product Name Alternative
BAY g 5421-d4
UNSPSC
12352005
Target
Glycosidase; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Smiles
OC([2H])([C@H]([C@H]1O[C@@H]2[C@H](O)[C@@H](O)[C@H](N[C@H]3C=C(C([2H])(O)[2H])[C@@H](O)[C@H](O)[C@H]3O)[C@@H](C)O2)O[C@H](O[C@@H]([C@@H]([C@H](C=O)O)O)[C@@H](CO)O)[C@H](O)[C@H]1O)[2H]
Molecular Formula
C25H39D4NO18
Molecular Weight
649.63
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Zhang Q, et al. Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats. PLoS One. 2013 Nov 18;8 (11) :e79697.|[3]Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864|[4]Hanefeld M, et al. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits [published correction appears in Expert Rev Cardiovasc Ther. 2009 Mar;7 (3) :330]. Expert Rev Cardiovasc Ther. 2008;6 (2) :153-163.|[5]Yee HS, et al. A review of the safety and efficacy of acarbose in diabetes mellitus. Pharmacotherapy. 1996;16 (5) :792-805.|[6]Oki T, et al. Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol Pharm Bull. 2000;23 (9) :1084-1087.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0089S/
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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