Amrubicin (hydrochloride)

Amrubicin (SM-5887) hydrochloride is a DNA topoisomerase II inhibitor, used for the research of cancer.

Product Specifications

CAS Number

[110311-30-3]

Product Name Alternative

SM-5887 (hydrochloride)

UNSPSC

12352005

Target

Bacterial; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Cancer

Purity

98.78

Solubility

DMSO : 100 mg/mL

Smiles

CC([C@@](C1)(N)C[C@H](O[C@@H]2OC[C@@H](O)[C@@H](O)C2)C(C1=C3O)=C(O)C4=C3C(C5=CC=CC=C5C4=O)=O)=O.Cl

Molecular Formula

C25H26ClNO9

Molecular Weight

519.93

References & Citations

[1]Hayashi S, et al. Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction. Int J Mol Med. 2006 Nov;18 (5) :909-15.|[2]Hanada M, et al. Amrubicin, a novel 9-aminoanthracycline, enhances the antitumor activity of chemotherapeutic agents against human cancer cells in vitro and in vivo. Cancer Sci. 2007 Mar;98 (3) :447-54.|[3]Hanada M, et al. Amrubicin induces apoptosis in human tumor cells mediated by the activation of caspase-3/7 preceding a loss of mitochondrial membrane potential. Cancer Sci. 2006 Dec;97 (12) :1396-403. Epub 2006 Sep 21.