Vigabatrin (hydrochloride) (Standard)

Vigabatrin (hydrochloride) (Standard) is the analytical standard of Vigabatrin (hydrochloride) . This product is intended for research and analytical applications. Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

Product Specifications

CAS Number

[1391054-02-6]

UNSPSC

12352100

Target

GABA Receptor; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

C=CC(N)CCC(O)=O.Cl

Molecular Formula

C6H12ClNO2

Molecular Weight

165.62

References & Citations

[1]Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46 (2), 362-376.|[2]Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12 (3), 275-286.|[3]Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473 (1-2) :395-7.