Polymyxin B1-D-Leu-d7 (TFA)
Polymyxin B1-D-Leu-d7 TFA is the deuterium labeled Polymyxin B1. Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment[1][2].
Product Specifications
UNSPSC
12352209
Target
Bacterial; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=C(N[C@@H](C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@H](O)C)=O)CCN)=O)([H])CCN)=O)CC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])[C@H](NC([C@@H](NC([C@@](CCNC1=O)([H])NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCC[C@@H](C)CC)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2.OC(C(F)(F)F)=O.[5]
Molecular Formula
C56H91D7N16O13.5C2HF3O2
Molecular Weight
1780.64
References & Citations
[1]Kwa AL, et al. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008 Feb;60 (2) :163-7. |[2]Berglund NA, et al. Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study. PLoS Comput Biol. 2015 Apr 17;11 (4) :e1004180.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Launched
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