Dalfopristin (mesylate)

Dalfopristin (RP54476) mesylate is a semisynthetic sulfone antibiotic. Dalfopristin mesylate alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci[1].

Product Specifications

Product Name Alternative

RP54476 (mesylate)

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=S(CC[NH+](CC)CC)([C@H]1[C@@](C(O[C@H]([C@@H](/C=C/C(NC/C=C\C(C)=C\2)=O)C)C(C)C)=O)([H])N(C(C3=COC(CC(C[C@@H]2O)=O)=N3)=O)CC1)=O.CS([O-])(=O)=O

Molecular Formula

C35H54N4O12S2

Molecular Weight

786.95

References & Citations

[1]A Le Liboux, et al. Simultaneous high-performance liquid chromatographic determination of quinupristin, dalfopristin and their main metabolites in human plasma. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708 (1-2) :161-8. |[2]Martinet MR, et al. Lack of effect of streptogramins on hepatic drug metabolism enzymes in the rat. Drug Metab Dispos. 1992 Jul-Aug;20 (4) :490-5.