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Norzine (dimalate)

Norzine dimalate (Thiethylperazine dimalate), a Phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Norzine dimalate is also a selective ABCC1activator that reduces amyloid-β load in mice. Norzine dimalate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

Product Specifications

CAS Number

52239-63-1

Product Name Alternative

Thiethylperazine (dimalate)

UNSPSC

12352005

Hazard Statement

H302-H410

Target

Amyloid-β; Bacterial; Dopamine Receptor; Drug Derivative; Histamine Receptor

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Infection; Neurological Disease

Smiles

O=C(O)C(O)CC(O)=O.CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)C(O)CC(O)=O

Molecular Formula

C30H41N3O10S2

Molecular Weight

667.79

Precautions

P264-P270-P273-P330-P391-P501

References & Citations

[1]Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110 (5) :497-9. |[2]Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121 (10) :3924-31. |[3]Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107 (2) :676-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

D2 Receptor; H1 Receptor

Available Sizes

Frequently Asked Questions

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