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Fenspiride (hydrochloride) (Standard)

Fenspiride (hydrochloride) (Standard) is the analytical standard of Fenspiride (hydrochloride) . This product is intended for research and analytical applications. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].

Product Specifications

CAS Number

5053-08-7

UNSPSC

12352100

Target

Histamine Receptor; Phosphodiesterase (PDE) ; Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Endocrinology

Smiles

O=C1OC2(CCN(CCC3=CC=CC=C3)CC2)CN1.Cl

Molecular Formula

C15H21ClN2O2

Molecular Weight

296.79

References & Citations

[1]Matuszewska A, et al. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. Adv Clin Exp Med. 2019 Jun;28 (6) :771-776.|[2]Cortijo J, et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study. Eur J Pharmacol. 1998 Jan 2;341 (1) :79-86.|[3]De Castro CM, et al. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. Eur J Pharmacol. 1995 Dec 29;294 (2-3) :669-76.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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