Decitabine-13C5

Decitabine-13C5 (5-Aza-2'-deoxycytidine-13C5) is 13C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity[1][2].

Product Specifications

Product Name Alternative

5-Aza-2'-deoxycytidine-13C5; 5-AZA-CdR-13C5; NSC 127716-13C5

UNSPSC

12352005

Target

Apoptosis; DNA Methyltransferase; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O[13CH]1[13C][13C@@H](N2C(N=C(N)N=C2)=O)O[13C@@H]1[13CH2]O

Molecular Formula

C3 13C5H10N4O4

Molecular Weight

231.15

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Parker WB. Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev. 2009 Jul;109 (7) :2880-93.|[3]Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33 (2) :75-85.|[4]Yu J, et al. DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine. J Clin Invest. 2018 Jun 1;128 (6) :2376-2388.|[5]Wang LX, et al. Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumorspecific cytotoxic T lymphocyte responses. PLoS One. 2013 May 9;8 (5) :e62924.|[6]Nakamura M, et al. Decitabine inhibits tumor cell proliferation and up-regulates E-cadherin expression in Epstein-Barr virus-associated gastric cancer. J Med Virol. 2016 Jul 19.|[7]Hagemann S, et al. Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One. 2011 Mar 7;6 (3) :e17388.|[8]Requena CE, et al. The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine. Biochem J. 2016 Jun 20.