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Tolterodine tartrate-d14

Tolterodine tartrate-d14 (Kabi-2234-d14) is deuterium labeled Tolterodine (tartrate) . Tolterodine Tartrate (Kabi-2234; PNU-200583E) is a potent muscarinic receptor antagonist and shows selectivity for the urinary bladder over salivary glands in vivo.

Product Specifications

CAS Number

1191280-48-4

Product Name Alternative

Kabi-2234-d14; PNU-200583E-d14

UNSPSC

12352005

Target

Isotope-Labeled Compounds; mAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Smiles

OC([C@H](O)[C@@H](O)C(O)=O)=O.OC(C=CC(C)=C1)=C1[C@@H](C2=CC=CC=C2)CCN(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]

Molecular Formula

C26H23D14NO7

Molecular Weight

489.66

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90 (5) :260-7.|[3]Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26 (6) :528-35.|[4]Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579 (1-3) :225-8.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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