Estrone 3-methyl ether

Estrone 3-methyl ether (Oestrone methyl ether; 3-O-Methylestrone) is a synthetic intermediate useful for synthesis of estrogen receptor modulator[1][2][3].

Product Specifications

CAS Number

[1624-62-0]

Product Name Alternative

Oestrone methyl ether; 3-O-Methylestrone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Cancer

Purity

98.82

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC)C=C4CC3

Molecular Formula

C19H24O2

Molecular Weight

284.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Kuznetsov YV, et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5 (10) -trienes: Synthesis, molecular modeling, and biological evaluation. Eur J Med Chem. 2018 Jan 1;143:670-682.|[2]Herman BE, et al. Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1. J Enzyme Inhib Med Chem. 2016;31 (sup3) :61-69.|[3]Kuznetsov YV, et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5 (10) -trienes: Synthesis, molecular modeling, and biological evaluation. Eur J Med Chem. 2018 Jan 1;143:670-682.