ON 01500

ON 01500 is a tubulin inhibitor with a Kd of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers[1][2].

Product Specifications

CAS Number

[592542-50-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Purity

99.07

Smiles

NC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC

Molecular Formula

C19H23NO6S

Molecular Weight

393.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Baker SJ, et al. A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent. Mol Cell. 2020 Jul 2;79 (1) :180-190.e4.|[2]Jost, Marco et al. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Molecular Cell, Volume 79, Issue 1, 191 - 198.e3