ON 01500
ON 01500 is a tubulin inhibitor with a Kd of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers[1][2].
Product Specifications
CAS Number
[592542-50-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Purity
99.07
Smiles
NC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC
Molecular Formula
C19H23NO6S
Molecular Weight
393.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Baker SJ, et al. A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent. Mol Cell. 2020 Jul 2;79 (1) :180-190.e4.|[2]Jost, Marco et al. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Molecular Cell, Volume 79, Issue 1, 191 - 198.e3
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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