2R,4S-Sacubitril (Standard)
2R,4S-Sacubitril (Standard) is the analytical standard of 2R,4S-Sacubitril. This product is intended for research and analytical applications. 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
Product Specifications
CAS Number
761373-05-1
UNSPSC
12352005
Target
Drug Metabolite; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
[H]N(C(CCC(O)=O)=O)[C@@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C(OCC)=O)C
Molecular Formula
C24H29NO5
Molecular Weight
411.49
References & Citations
[1]Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44 (4) :554-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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