2R,4S-Sacubitril (Standard)

2R,4S-Sacubitril (Standard) is the analytical standard of 2R,4S-Sacubitril. This product is intended for research and analytical applications. 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

Product Specifications

CAS Number

[761373-05-1]

UNSPSC

12352005

Target

Drug Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Smiles

[H]N(C(CCC(O)=O)=O)[C@@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C(OCC)=O)C

Molecular Formula

C24H29NO5

Molecular Weight

411.49

References & Citations

[1]Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44 (4) :554-9.