RU 56279

RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 (HY-117486) and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells[1][2].

Product Specifications

CAS Number

[143782-20-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor; Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Purity

99.68

Smiles

CC(C1=O)(C)NC(N1C2=CC(C(F)(F)F)=C(C#N)C=C2)=O

Molecular Formula

C13H10F3N3O2

Molecular Weight

297.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Cousty-Berlin D, et al. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. J Steroid Biochem Mol Biol. 1994 Oct;51 (1-2) :47-55.|[2]Cogan PS, Koch TH. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. J Med Chem. 2003 Nov 20;46 (24) :5258-70.