7-Deazaxanthine
7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase) . 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect[1].
Product Specifications
CAS Number
[39929-79-8]
Product Name Alternative
7DX
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Thymidylate Synthase
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Purity
99.72
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(C2=C(N1)NC=C2)=O
Molecular Formula
C6H5N3O2
Molecular Weight
151.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Balzarini J, et al. 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. FEBS Lett. 1998 Oct 30;438 (1-2) :91-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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