SB-408124 (Hydrochloride) (Standard)
SB-408124 (Hydrochloride) (Standard) is the analytical standard of SB-408124 (Hydrochloride) . This product is intended for research and analytical applications. SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor[1].
Product Specifications
CAS Number
1431697-90-3
UNSPSC
12352100
Target
Orexin Receptor (OX Receptor) ; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology
Smiles
O=C(NC1=CC=C(C=C1)N(C)C)NC2=CC(C)=NC(C2=CC(F)=C3)=C3F.[H]Cl
Molecular Formula
C19H19ClF2N4O
Molecular Weight
392.83
References & Citations
[1]Langmead et al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340.|[2] I Tissen, et al. OX1R ANTAGONIST SB408124 ACTION AND EXTRAHYPOTHALAMIC CRF IN RATS AFTER PSYCHOTRAUMATIC EXPOSURE. Georgian Med News. 2019 May; (290) :127-131.|[3]Michael J Huber, et al. Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313 (6) :H1075-H1086.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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