ML-10
ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1].
Product Specifications
CAS Number
[1216897-16-3]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer; Cardiovascular Disease
Purity
95.0
Smiles
O=C(O)C(C)(CCCCCF)C(O)=O
Molecular Formula
C9H15FO4
Molecular Weight
206.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Cohen A, et al. From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res. 2009 May;19 (5) :625-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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