6-Chloro-7-deazaguanine

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively[1].

Product Specifications

CAS Number

[84955-31-7]

UNSPSC

12352005

Hazard Statement

H319

Target

IKK

Related Pathways

NF-κB

Field of Research

Cancer

Purity

99.83

Solubility

H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC(Cl)=C2C(NC=C2)=N1

Molecular Formula

C6H5ClN4

Molecular Weight

168.58

Precautions

H319

References & Citations

[1]Anthony NG, Baiget J, Berretta G, Boyd M, Breen D, Edwards J, Gamble C, Gray AI, Harvey AL, Hatziieremia S, Ho KH, Huggan JK, Lang S, Llona-Minguez S, Luo JL, McIntosh K, Paul A, Plevin RJ, Robertson MN, Scott R, Suckling CJ, Sutcliffe OB, Young LC, Mackay SP. Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers. J Med Chem. 2017 Aug 24;60 (16) :7043-7066.