Tacedinaline (Standard)
Tacedinaline (Standard) is the analytical standard of Tacedinaline. This product is intended for research and analytical applications. Tacedinaline (N-acetyldinaline) is an inhibitor of the histone deacetylase (HDAC) with IC50s of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively.
Product Specifications
CAS Number
112522-64-2
UNSPSC
12352100
Target
Apoptosis; HDAC; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(NC1=C(N)C=CC=C1)C2=CC=C(NC(C)=O)C=C2
Molecular Formula
C15H15N3O2
Molecular Weight
269.30
References & Citations
[1]Moradei OM, et al. Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50 (23) :5543-6.|[2]Loprevite M, etal. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines. Oncol Res. 2005;15 (1) :39-48.|[3]LoRusso PM, et al. Preclinical antitumor activity of CI-994. Invest New Drugs. 1996;14 (4) :349-56.|[4]Graziano MJ, et al. Immunotoxicity of the anticancer drug CI-994 in rats: effects on lymphoid tissue. Arch Toxicol. 1999 Apr-May;73 (3) :168-74.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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