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Plerixafor (octahydrochloride) (Standard)

Plerixafor (octahydrochloride) (Standard) is the analytical standard of Plerixafor (octahydrochloride) . This product is intended for research and analytical applications. Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM.

Product Specifications

CAS Number

155148-31-5

UNSPSC

12352100

Target

CXCR; HIV; Reference Standards; Virus Protease

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Smiles

[H]Cl.N1(CCCNCCNCCCNCC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.[8]

Molecular Formula

C28H54N8.8HCl

Molecular Weight

794.47

References & Citations

[1]Zabel BA, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183 (5) :3204-11.|[2]Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55.|[3]Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11 (2) :e0149926.|[4]Chu PY, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10 (7) :e0133616.|[5]Schols D, et al. HIV co-receptor inhibitors as novel class of anti-HIV drugs. Antiviral Res. 2006 Sep;71 (2-3) :216-26.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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