Plerixafor (octahydrochloride) (Standard)
Plerixafor (octahydrochloride) (Standard) is the analytical standard of Plerixafor (octahydrochloride) . This product is intended for research and analytical applications. Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM.
Product Specifications
CAS Number
155148-31-5
UNSPSC
12352100
Target
CXCR; HIV; Reference Standards; Virus Protease
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Endocrinology; Cancer
Smiles
[H]Cl.N1(CCCNCCNCCCNCC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.[8]
Molecular Formula
C28H54N8.8HCl
Molecular Weight
794.47
References & Citations
[1]Zabel BA, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183 (5) :3204-11.|[2]Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55.|[3]Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11 (2) :e0149926.|[4]Chu PY, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10 (7) :e0133616.|[5]Schols D, et al. HIV co-receptor inhibitors as novel class of anti-HIV drugs. Antiviral Res. 2006 Sep;71 (2-3) :216-26.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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