Perifosine (Standard)
Perifosine (Standard) is the analytical standard of Perifosine. This product is intended for research and analytical applications. Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC50s of 0.6-8.9 μM.
Product Specifications
CAS Number
157716-52-4
UNSPSC
12352100
Target
Akt; Apoptosis; Autophagy; Reference Standards
Related Pathways
Apoptosis; Autophagy; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
[O-]P(OC1CC[N+](C)(CC1)C)(OCCCCCCCCCCCCCCCCCC)=O
Molecular Formula
C25H52NO4P
Molecular Weight
461.66
References & Citations
[1]Momota H, et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res, 2005, 65 (16), 7429-7435.|[2]Vyomesh Patel, et al. Perifosine, a novel alkylphospholipid, induces p21 (WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res, 2002, 62 (5), 14|[3]Chen L, et al. Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia. 2012 Nov;53 (11) :2026-33.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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