Gefitinib (hydrochloride) (Standard)
Gefitinib (hydrochloride) (Standard) is the analytical standard of Gefitinib (hydrochloride) . This product is intended for research and analytical applications. Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity[1][2].
Product Specifications
UNSPSC
12352100
Target
EGFR; Reference Standards
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F.[H]Cl
Molecular Formula
C22H25Cl2FN4O3
Molecular Weight
483.36
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-50895AR/
Scientific Category
Reference Standards
CAS Number
[184475-55-6]
Available Sizes
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