CI-1040 (hydrochloride)
CI-1040 (PD 184352) hydrochloride is an orally active, highly specific inhibitor of MEK, with an IC50 of 17 nM for MEK1[1][2][3].
Product Specifications
Product Name Alternative
PD 184352 (hydrochloride)
UNSPSC
12352101
Target
Apoptosis; MEK
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3.Cl
Molecular Formula
C17H15Cl2F2IN2O2
Molecular Weight
515.12
References & Citations
[1]Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) . Semin Oncol. 2003 Oct;30 (5 Suppl 16) :105-16.|[2]Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20 (10) :1961-8. [Content Brief]|[3]Kramer BW, et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK1
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