Mardepodect (hydrochloride) (Standard)
Mardepodect (hydrochloride) (Standard) is the analytical standard of Mardepodect (hydrochloride) . This product is intended for research and analytical applications. Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier[1][2].
Product Specifications
CAS Number
2070014-78-5
UNSPSC
12352100
Target
Phosphodiesterase (PDE) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
CN1N=C(C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C(C5=CC=NC=C5)=C1.Cl[H]
Molecular Formula
C25H21ClN4O
Molecular Weight
428.91
References & Citations
[1]Wilson JM et al. Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in D2 neurons than in D1 neurons in the neostriatum. Neuropharmacology. 2015 Dec;99:379-86.|[2]Verhoest PR et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4- (1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl) -phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem. 2009 Aug 27;52 (16) :5188-96.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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