3-Epideoxycholic acid

3-Epideoxycholic acid is the microbial metabolite of Deoxycholic acid (HY-N0593) . 3-Epideoxycholic acid targets FXR of dendritic cells, reduces their immunostimulatory properties, promotes the generation of Treg cells, and exhibits anti-inflammatory activity. 3-Epideoxycholic acid promotes the growth of bacteria Bacteroides[1][2].

Product Specifications

CAS Number

[570-63-8]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; FXR

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

99.90

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@H](CC4)O)([H])CC3)C

Molecular Formula

C24H40O4

Molecular Weight

392.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Campbell C, et al., Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020 May;581 (7809) :475-479. |[2]Devlin AS, et al., A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat Chem Biol. 2015 Sep;11 (9) :685-90.