AKT ligand-2
AKT ligand-2 (compound 5) is an AKT ligand. AKT ligand-2 can be combined with VHL ligand (S, R, S) -AHPC through linker to synthesize PROTAC MS21 (HY-141807).
Product Specifications
CAS Number
2376139-61-4
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
ClC(C=C1)=CC=C1[C@H](CCN2CCNCC2)NC(C3(CCN(C4=C5C(NC=C5)=NC=N4)CC3)NC(OC(C)(C)C)=O)=O
Molecular Formula
C30H41ClN8O3
Molecular Weight
597.15
References & Citations
[1]Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Dec
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Frequently Asked Questions
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