AKT ligand-2

AKT ligand-2 (compound 5) is an AKT ligand. AKT ligand-2 can be combined with VHL ligand (S, R, S) -AHPC (HY-125845) through linker to synthesize PROTAC MS21 (HY-141807) [1].

Product Specifications

CAS Number

[2376139-61-4]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

ClC(C=C1)=CC=C1[C@H](CCN2CCNCC2)NC(C3(CCN(C4=C5C(NC=C5)=NC=N4)CC3)NC(OC(C)(C)C)=O)=O

Molecular Formula

C30H41ClN8O3

Molecular Weight

597.15

References & Citations

[1]Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Dec