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3,9-Dimethyl-3,9-diazaspiro[5.5]undecane

3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid PROTAC linker can be used in the synthesis of PROTACs, such as FIP22. FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity[1].

Product Specifications

CAS Number

93004-48-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Related Pathways

PROTAC

Field of Research

Inflammation/Immunology

Purity

99.98

Smiles

CN(CC1)CCC21CCN(C)CC2

Molecular Formula

C11H22N2

Molecular Weight

182.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Fan Y, et al. Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Aug 28;68 (16) :17874-17896.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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