TBuO-Ste-Glu (AEEA-AEEA-OH) -OtBu

TBuO-Ste-Glu (AEEA-AEEA-OH) -OtBu is an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist Semaglutide (HY-114118) .

Product Specifications

CAS Number

[1118767-16-0]

Product Name Alternative

Semaglutide side chain

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

GLP Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

98.04

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(O)COCCOCCNC(COCCOCCNC(CC[C@@H](C(OC(C)(C)C)=O)NC(CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O)=O)=O)=O

Molecular Formula

C43H79N3O13

Molecular Weight

846.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Thomas B Kjeldsen, et al. Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320. J Med Chem. 2021 Jan 14;64 (1) :616-628.